Traditional drug therapy faces challenges such as drug Ball - Accessories distribution throughout the body, rapid degradation and excretion, and extensive adverse reactions.In contrast, micro/nanoparticles can controllably deliver drugs to target sites to improve drug efficacy.Unlike traditional large-scale synthetic systems, microfluidics allows manipulation of fluids at the microscale and shows great potential in drug delivery and precision medicine.Well-designed microfluidic devices have been used to fabricate multifunctional drug carriers using stimuli-responsive materials.
In this review, we first introduce the selection of materials and processing techniques for microfluidic devices.Then, various well-designed microfluidic chips eme are shown for the fabrication of multifunctional micro/nanoparticles as drug delivery vehicles.Finally, we describe the interaction of drugs with lymphatic vessels that are neglected in organs-on-chips.Overall, the accelerated development of microfluidics holds great potential for the clinical translation of micro/nanoparticle drug delivery systems for disease treatment.